Table 3.
Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of different combinations of the 3 protein markers in the diagnosis of papillary thyroid carcinoma
| Protein markers combination | Sensitivity | specificity | PPV | NPV | Accuracy |
|---|---|---|---|---|---|
| CK19 + and TPO- | 98.50% | 77.90% | 93.10% | 94.60% | 93.40% |
| CK19 + and HBME-1+ | 97.40% | 51.00% | 82.60% | 89.30% | 83.70% |
| HBME-1+ and TPO- | 94.30% | 92.90% | 96.10% | 89.70% | 93.80% |
| CK19 +, TPO- and HBME-1+ | 98.00% | 89.30% | 97.00% | 92.60% | 96.10% |
CK-19, cytokeratin-19; TPO, thyroid peroxidase; HBME-1, human bone marrow endothelial cell-1.