Table 2.
Relation between T2D-associated SNPs and altered serum adipocytokine levels
| Risk Allele | Model | Adiponectin Odds Ratio (95% CI) | P value | Resistin Odds Ratio (95% CI) | P value | aPAI Odds Ratio (95% CI) | P value | |
|---|---|---|---|---|---|---|---|---|
| rs7903146 | T | Additive | 1.5 (0.88, 2.7) | 0.11 | 1.1 (0.64, 1.9) | 0.65 | 1.0 (0.53, 1.9) | 0.95 |
| Recessive | 1.6 (0.96, 2.8) | 0.06 | 1.2 (0.70, 2.0) | 0.51 | 1.4 (0.76, 2.5) | 0.27 | ||
| Dominant | 1.0 (0.71, 1.5) | 0.85 | 0.95 (0.66, 1.3) | 0.81 | 0.61 (0.39, 0.96) | 0.03 | ||
| rs13081389 | A | Additive | - | - | - | - | 3.2 (1.3, 7.3) | 0.007 |
| Recessive | 1.2 (0.61, 2.1) | 0.64 | 1.6 (0.83, 3.0) | 0.15 | 3.2 (1.3, 7.3) | 0.007 | ||
| Dominant | - | - | - | - | - | - | ||
| rs1470579 | C | Additive | 0.71 (0.42, 1.1) | 0.18 | 1.5 (0.95, 2.5) | 0.07 | 2.1 (1.1, 3.8) | 0.02 |
| Recessive | 0.77 (0.48, 1.2) | 0.28 | 1.4 (0.92, 2.3) | 0.10 | 1.9 (1.1, 3.4) | 0.02 | ||
| Dominant | 0.79 (0.54, 1.1) | 0.22 | 1.3 (0.89, 1.8) | 0.18 | 1.3 (0.85, 2.1) | 0.19 | ||
| rs243021 | T | Additive | 1.1 (0.59, 1.8) | 0.86 | 0.82 (0.47, 1.4) | 0.49 | 0.48 (0.24, 0.96) | 0.04 |
| Recessive | 0.90 (0.62, 1.3) | 0.59 | 1.0 (0.72, 1.4) | 0.83 | 0.59 (0.38, 0.94) | 0.02 | ||
| Dominant | 1.1 (0.67, 1.9) | 0.63 | 0.77 (0.46, 1.3) | 0.33 | 0.62 (0.32, 1.2) | 0.14 | ||
| rs972283 | G | Additive | 1.6 (1.0, 2.9) | 0.04 | 1.5 (0.87, 2.5) | 0.14 | 1.5 (0.77, 2.9) | 0.22 |
| Recessive | 1.2 (0.81, 1.7) | 0.38 | 1.3 (0.89, 1.8) | 0.17 | 1.1 (0.69, 1.7) | 0.71 | ||
| Dominant | 1.6 (1.0, 2.7) | 0.04 | 1.3 (0.81, 2.2) | 0.25 | 1.5 (0.82, 2.8) | 0.17 | ||
| rs896854 | A | Additive | 2.7 (1.6, 4.6) | 1.04*10-4 | 0.81 (0.49, 1.3) | 0.39 | 1.3 (0.74, 2.4) | 0.32 |
| Recessive | 1.68 (1.1, 2.5) | 0.01 | 0.81 (0.54, 1.2) | 0.31 | 1.1 (0.71, 1.8) | 0.56 | ||
| Dominant | 2.4 (1.5, 3.6) | 1.05*10-4 | 0.92 (0.61, 1.3) | 0.67 | 1.3 (0.79, 2.1) | 0.29 | ||
| rs13292136 | C | Additive | 0.65 (0.18, 2.3) | 0.51 | 0.36 (0.09, 1.4) | 0.13 | 0.10 (0.01, 0.93) | 0.03 |
| Recessive | 0.65 (0.18, 2.3) | 0.51 | 0.36 (0.09, 1.4) | 0.13 | 0.11 (0.01, 0.83) | 0.03 | ||
| Dominant | - | - | - | - | - | - | ||
| rs1552224 | T | Additive | - | - | - | - | - | - |
| Recessive | 1.3 (0.59, 2.8) | 0.52 | 0.59 (0.27, 1.2) | 0.18 | 0.29 (0.09, 0.91) | 0.03 | ||
| Dominant | - | - | - | - | - | - | ||
| rs11634397 | G | Additive | 1.4 (0.82, 2.3) | 0.22 | 1.0 (0.62, 1.7) | 0.87 | 0.76 (0.41, 1.4) | 0.38 |
| Recessive | 1.7 (1.1, 2.5) | 0.01 | 1.2 (0.83, 1.8) | 0.29 | 0.96 (0.59, 1.5) | 0.86 | ||
| Dominant | 0.94 (0.60, 1.4) | 0.94 | 0.87 (0.56, 1.3) | 0.54 | 0.73 (0.43, 1.2) | 0.25 | ||
| rs5945326 | G | Additive | 0.66 (0.29, 1.4) | 0.32 | 1.5 (0.69, 3.4) | 0.28 | 1.1 (0.48, 2.6) | 0.76 |
| Recessive | 0.72 (0.32, 1.6) | 0.43 | 1.5 (0.67, 3.3) | 0.32 | 1.1 (0.47, 2.5) | 0.81 | ||
| Dominant | 0.56 (0.35, 0.91) | 0.02 | 1.3 (0.85, 2.1) | 0.19 | 1.3 (0.69, 2.3) | 0.43 | ||
| rs163184 | G | Additive | 1.2 (0.71, 1.9) | 0.50 | 0.97 (0.59, 1.6) | 0.92 | 0.61 (0.33, 1.1) | 0.11 |
| Recessive | 1.3 (0.85, 2.0) | 0.20 | 1.1 (0.70, 1.6) | 0.74 | 0.85 (0.50, 1.4) | 0.55 | ||
| Dominant | 0.94 (0.63, 1.4) | 0.79 | 0.90 (0.60, 1.3) | 0.61 | 0.59 (0.36, 0.96) | 0.03 | ||
| rs4812829 | A | Additive | 0.37 (0.14, 0.98) | 0.04 | 0.98 (0.40, 2.3) | 0.96 | 1.2 (0.39, 3.7) | 0.72 |
| Recessive | 0.38 (0.14, 1.0) | 0.05 | 0.90 (0.37, 2.1) | 0.81 | 1.2 (0.38, 3.5) | 0.78 | ||
| Dominant | 0.81 (0.55, 1.2) | 0.28 | 1.2 (0.85, 1.8) | 0.27 | 1.1 (0.72, 1.7) | 0.59 |