Table 2.
Body weight, energy intake, lipid profile and liver function of the rats
| ND | HFD | Pioglitazone | JLD (0.75 g/Kg) | JLD (1.5 g/Kg) | JLD (3 g/Kg) | |
|---|---|---|---|---|---|---|
| Body weight (g) | 471.50±4.53* | 644.83±15.77 | 539.00±10.55*,# | 583.5±17.41*,# | 540.67±17.43*,# | 526.50±18.08*,# |
| Energy intake (kcal/day) | 87.32±6.01* | 117.06±6.25 | 110.34±7.92 | 109.83±6.04 | 101.59±5.05 | 103.26±7.33 |
| APN (ng/mL) | 17.43±0.93* | 12.68±0.93 | 22.17±1.25*,# | 18.28±1.01* | 20.31±1.14* | 17.14±0.82* |
| Lipid profile | ||||||
| TG (mmol/L) | 0.37±0.03* | 0.52±0.03 | 0.23±0.03*,# | 0.26±0.02*,# | 0.15±0.01*,# | 0.16±0.01*,# |
| NEFA (mmol/L) | 0.64±0.05* | 1.40±0.08 | 0.76±0.05* | 0.88±0.06* | 0.76±0.06* | 0.77±0.08* |
| TC (mmol/L) | 1.04±0.07 | 1.15 ±0.05 | 1.01±0.06 | 0.76±0.08* | 0.75±0.05* | 0.84±0.07* |
| Liver function | ||||||
| ALT (IU/L) | 42.25±3.47* | 116.98±4.90 | 46.52±2.70* | 84.77±3.29#,* | 66.25±5.32#,* | 88.48±2.30#,* |
| AST (IU/L) | 119.38±4.44* | 218.67±5.12 | 141.63±4.44#,* | 161.18±3.94#,* | 132.98±3.44#,* | 169.18±5.74#,* |
| TBIL (μmol/L) | 0.56±0.05 | 0.81±0.08 | 0.70±0.06 | 0.74±0.06 | 0.71±0.06 | 0.69±0.07 |
Data are means ± SD. n = 6 per group.
*
P < 0.05 compared with the HFD group;
#
P < 0.05 compared with the ND group.
APN: adiponectin; TG: triglyceride; NEFA: nonesterified fatty acid; TC: total cholesterol; ALT: alanine aminotransferase; AST: aspartate aminotransferase; TBIL: total bilirubin. 12. 68±0.93.