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. 2015 May 7;38(5):441–451. doi: 10.14348/molcells.2015.2359

Fig. 3.

Fig. 3.

STING inhibits dsDNA-induced activation of the JAK1-STAT1 signaling. (A, B) BJAB cells were tansfected with si-STING or si-NC for 36 h and then tansfected with poly(dA:dT) for 30 min or 6 h. The expression levels of IFIT1, MX1, OAS1 and IFI44 were detected at 6 h by qPCR (A). The phosphorylation of JAK1 was detected at 30 min by Western blot (B). (C, D) BJAB cells were tansfected with pcDNA3.1-STING or control plasmid for 36 h and then tansfected with poly(dA:dT) for 30 min or 6 h. The expression levels of IFIT1, IFI44, MX1 and OAS1 were detected at 6 h by qPCR (C). The phosphorylation of JAK1 and STAT1 were detected at 30 min by western blot (D). The data shown represent the means of three independent experiments, and the error bars represent the s.e.m. *p < 0.05, **p < 0.01, ***p < 0.001; ns denotes p > 0.05.