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. 2015 Apr 21;4(6):493–506. doi: 10.1016/j.molmet.2015.04.001

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© 2015 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

GPx4 content and HNE-adducts in human myocardium. Total GPx4 enzyme content A and HNE-adducts B are shown in atrial myocardium obtained from non-diabetic and diabetic patients undergoing elective heart surgery. Shown in C is association between HNE-adducts and GPx4 enzyme in these heart samples, and the ratio of HNE-adduct to GPx4 enzyme are depicted in D. Each symbol corresponds to one individual patient (N = 103, see Table 2 for demographics and clinical variables). P-value computed using Friedman's nonparametric test for central tendency, adjusting for sex.