Table 3.
Multivariable analysis of GPx4 and HNE-adducts in human heart.
| GPx4 content (ug/ml) | |||
| Diabetes n (%) |
No diabetes n (%) |
RR (95% CI)a | |
| Mean ± SD | 6.2 ± 4.2 | 8.7 ± 5.9 | P = 0.034b |
| Median (IQR) | 6.0 (5.2) | 6.7 (6.6) | |
| Q1 (≤3.9) | 17 (35) | 9 (17) | 1.0 Referent |
| Q2 (>3.9–6.3) | 10 (20) | 15 (28) | 0.65 (0.37–1.1) |
| Q3 (>6.3–9.4) | 13 (27) | 13 (24) | 0.74 (0.47–1.2) |
| Q4 (>9.4) | 9 (18) | 17 (31) | 0.58 (0.31–1.1) |
| Ptrend = 0.063c | |||
| HNE content (mM) | |||
| Mean ± SD | 18 ± 8.3 | 14 ± 9.8 | P = 0.028b |
| Median (IQR) | 16 (11) | 11 (12) | |
| T1 (≤9.0) | 3 (10) | 21 (47) | 1.0 Referent |
| T2 (>9.0–17) | 14 (47) | 11 (24) | 4.2 (1.4–13) |
| T3 (>17) | 13 (43) | 13 (29) | 3.9 (1.2–12) |
| Ptrend = 0.050c | |||
a
Relative Risk (RR) and 95% Confidence Interval (CI), adjusted for sex.
b
P-value computed using Friedman's Nonparametric test for central tendency, adjusting for sex.
c
P-value computed using the likelihood ratio trend test, adjusting for sex.