Fig. 4.
Effects of noise rearing on spike generation and fidelity of BC spiking. (A) Representative current-clamp recordings in response to current pulses of 0.6 nA in control and noise-reared BCs. (B) Average measurements of 30 BCs from control and 32 BCs from noise-reared mice, showing significant decreases in action potential peak voltage (Top, P = 0.03), threshold voltage (Middle, P < 0.005), and spike half-width (Bottom, P < 0.05). (C) Representative traces showing responses to fiber stimulation at 100 (Top) and 333 Hz (Bottom) in BCs from control (Left) and noise-reared (Right) mice. (D) Cumulative frequency histogram of spike probability (Pspike) over the second half of the stimulation train (pulses 11–20), for experiments similar to C. Pspike increased significantly after noise rearing (P < 0.05, asterisks) for both 100 (i) and 333 (ii) Hz.