Table 2. Differential Urinary Metabolites for Diagnosis of Depression in Hepatitis B Virus-Infected Patients.

No	Metabolite	Ra	P Valueb	Chemical Shift/ppm Multiplicityc
1	3, 4-Dihydroxymandelate	0.520	1.97 E-10	6.87, d; 6.92, s; 6.98, d
2	Acetamide	0.392	4.32 E-12	2.00, s
3	Acetoacetate	-0.276	3.62 E-07	2.27, s; 3.43, s
4	Acetone	0.817	1.41 E-09	2.22, s
5	Dimethylglycine	0.432	1.32 E-10	2.78, s
6	Glycerophosphocholine	-0.375	1.04 E-05	3.23, s
7	Glycolate	0.571	8.62 E-12	3.59, s
8	Isobutyrate	0.826	2.80 E-12	1.14, d
9	Malonate	-0.393	3.95 E-02	3.12, s
10	N-Methylnicotinamide	0.386	2.62 E-07	8.21, d; 8.90, d; 8.97, d; 9.29, s
11	Phenylacetylglycine	-0.527	8.85 E-04	7.28, d; 7.36, t; 7.42, dd
12	p-Hydroxyphenylacetate	-0.571	5.39 E-04	3.78, s; 7.14, d; 7.21, d
13	Pyruvate	0.491	6.50 E-15	2.38, s
14	Trimethylamine	0.479	3.10 E-12	2.88, s
15	α-Hydroxybutyrate	0.686	1.21 E-12	1.64, m; 1.73, m;3.99, dd
16	α-Hydroxyisobutyrate	0.404	3.89 E-13	3.69, m; 2.65, m;1.11, d
17	β-Hydroxybutyrate	0.531	9.12 E-07	1.24, d; 2.33, dd; 2.40, dd

^aCorrelation coefficient was obtained from OPLS-DA with a threshold of 0.273, positive value indicates higher levels, and negative value indicates lower levels in hepatitis B patients with depression.

^bP values were derived from non-parametric Mann-Whitney U test.

^cMultiplicity: d, doublet; dd, doublet of doublets; m, multiplet; q, quartet; s, singlet; t, triplet.