(A) view from within the plane of the membrane; (B) view from outside of the cell. Components shown in the figure are: two band 3 homodimers (red), one Rh/RhAG heterotrimer (RhAG light blue, RhCE mid-blue, RhD dark blue), one GPA homodimer (mint-green), one GPA/GPB heterodimer (mint-green/lime-green), one ICAM-4 monomer (yellow), one CD47 monomer (orange), two GLUT1 monomers (purple), one protein 4.2 monomer (pink) and one ankyrin monomer (green). All components are shown with secondary structure elements highlighted as cartoons and residues predicted to be disordered displayed as spheres centred on the Cα atoms. For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.