Table 1.
Multivariate logistic regression analysis of alleles and genotypes of T2DM cases and controls with and without using covariates.
| SNP | Allele | Adjusted for covariates |
Genotype | Adjusted for covariates |
|||||
|---|---|---|---|---|---|---|---|---|---|
| OR† | 95%C.I. | p-Value‡ | OR | 95%C.I. | p-Value‡ | ||||
| Gene± | |||||||||
| TCFL2 | rs7903146 | T | 2.02 | 1.61–2.52 | < 0.001 | CT | 1.99 | 1.49–2.64 | < 0.001⁎ |
| TT | 3.58 | 2.09–6.13 | < 0.001 | ||||||
| IGF2BP2 | rs1470579 | C | 1.31 | 1.07–1.61 | 0.009 | CA | 1.27 | 0.91–1.76 | 0.161 |
| CC | 1.22 | 0.83–1.78 | 0.312 | ||||||
| SLC30A8 | rs13266634 | C | 1.19 | 0.94–1.51 | 0.156 | CT | 1.09 | 0.56–2.11 | 0.799 |
| CC | 1.1 | 0.57–2.10 | 0.777 | ||||||
| CDKAL1 | rs7756992 | G | 1.3 | 1.03–1.64 | 0.025 | AG | 1.3 | 0.98–1.73 | 0.068 |
| GG | 1.97 | 1.09–3.56 | 0.025 | ||||||
| CDKN2A/B | rs10811661 | T | 1.2 | 0.91–1.59 | 0.188 | CT | 0.64 | 0.21–1.97 | 0.433 |
| TT | 0.95 | 0.31–2.87 | 0.927 | ||||||
| HHEX | rs1111875 | G | 0.79 | 0.65–0.98 | 0.028 | AG | 1.11 | 0.81–1.51 | 0.516 |
| GG | 0.88 | 0.59–1.30 | 0.52 | ||||||
| IRS-1 | rs1801278 | A | 1.21 | 0.74–1.99 | 0.45 | AA | 1.46 | 0.12–18.01 | 0.77 |
| GA | 1.45 | 0.85–2.47 | 0.175 | ||||||
| CAPN10 | rs3792267 | A | 1.81 | 0.89–1.56 | 0.242 | AA | 1.58 | 0.66–3.77 | 0.307 |
| GA | 1.27 | 0.92–1.74 | 0.147 | ||||||
| PPARG | rs1801282 | C | 1.14 | 0.84–1.54 | 0.413 | GC | 0.7 | 0.50–0.99 | 0.046 |
| GG | 1.22 | 0.41–3.59 | 0.721 | ||||||
| Covariates | |||||||||
| Age | 0.99 | 0.98–1.00 | 0.069 | 0.99 | 0.97–1.01 | 0.217 | |||
| Gender | 0.74 | 0.58–0.94 | 0.012 | 0.7 | 0.50–0.99 | 0.045 | |||
| Migration | 0.45 | 0.37–0.55 | < 0.001 | 0.44 | 0.33–0.58 | < 0.001 | |||
| V/NV | 0.67 | 0.52–0.85 | 0.001 | 0.68 | 0.48–0.97 | 0.035 | |||
| Junk food | 1.41 | 1.14–1.75 | 0.002 | 1.36 | 0.99–1.86 | 0.055 | |||
| Alcohol | 1.1 | 0.86–1.40 | 0.44 | 1.13 | 0.8–1.66 | 0.497 | |||
| Smoking | 0.68 | 0.51–0.90 | 0.007 | 0.65 | 0.43–0.99 | 0.046 | |||
| Physical activity | 1.19 | 1.06–1.33 | 0.003 | 1.18 | 1.0–1.4 | 0.048 | |||
| BMI | 1.16 | 1.13–1.19 | < 0.001 | 1.16 | 1.12–1.2 | < 0.001 | |||
±
Gene name — Abbreviation: Transcription factor 7 like 2 — TCF7L2, insulin growth factor2 mRNA binding protein 2 — IGF2BP2, solute carrier (Zinc transporter) 30 member 8 — SLC30A8, CDK5 regulatory subunit associated protein 1 — like 1 — CDKAL1, Cyclin-dependent kinase inhibitor 2A/B — CDKN2A/B, Hematopoietically expressed homeo box gene — HHEX, Insulin receptor substrate1—IRS1, Calcium activated cysteine protease — CAPN10, Peroxisome proliferator activated receptor gamma—PPARG.
‡
5% and 10% significance was considered.
†
Odds ratio calculated with respect to risk allele.
⁎
Significant p values bolded.