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. Author manuscript; available in PMC: 2015 May 26.
Published in final edited form as: Cell Stem Cell. 2015 May 7;16(5):488–503. doi: 10.1016/j.stem.2015.04.003

Figure 7. Neurogenesis and Astrogliogenesis in Inducible Nestin-CreER(T2)/R26R:YFP Transgenic Mice.

Figure 7

(A) Confocal microscopy images from 20-µm-thick z stacks of the DG after staining for YFP show the neurogenic effect of EA and the reactive-astrogliogenic effect of MTLE at 30 dpKAi.

(B–D) Quantification of the absolute number of YFP+ cells and the relative number of YFP+ cell types at 3 dpKAi (B), 14 dpKAi (C), and 30 dpKAi (D). The total number of YFP-positive cells increased significantly in the EA and MTLE mice in comparison to the Sal group. The neuronal fate of YFP+ cells (number of NeuN+YFP+ cells) was significantly promoted in EA mice, whereas the astroglial fate (GFAP+YFP+ or S100β+YFP+) was favored in MTLE mice.

*p < 0.05, **p < 0.01, ***p < 0.001 by all pairwise multiple comparisons by Holm-Sidak post hoc test. Bars show mean ± SEM. Dots show individual data.