Table 1.

Clinical characteristics of the patients, indicating the degree of marrow infiltration on bone marrow trephine, serum paraprotein and light chain concentrations, and the range of CRAB features present in this cohort.

Patient no.	Age (years)	Sex	Myeloma type	Affected cells on BMT (%)	Serum M-protein (g/l)	Serum free κ (mg/l)	Serum free λ (mg/l)	Corrected serum Calcium (mmol/l)	Serum creatinine (μmol/l)	Haemoglobin (g/dl)	Bone lesions
1	61	M	Non Secretory	60	0	<6	5	2.19	70	12.2	N
2	65	F	κ light chain	80	0	2100	<5	2.41	77	9.3	Y
3	70	F	IgG κ	25	13	1175	<5	2.20	55	12.9	Y
4	72	F	IgG κ	20-25	20	ND	ND	2.40	78	14.0	N
5	61	M	IgG κ	ND	13	56	<5	2.24	104	8.4	Y
6	67	M	IgA λ	25-35	37	10	5000	2.50	262	10.1	Y
7	60	F	IgG λ	2-5	6	<4	37	2.31	51	12.8	N
8	67	M	IgG κ	80	8	15	9	2.30	136	13.8	Y
9	65	M	IgG λ	10-20	0	7	1275	2.16	87	12.4	Y
10	55	F	λ light chain	20-30	0	7	650	2.44	59	11.2	Y
11	62	F	IgG κ	25	13	ND	ND	2.30	65	11.6	N
12	65	F	IgG κ	60-70	49	ND	ND	2.28	83	10.4	Y
13	68	F	IgG κ	10-20	28	ND	ND	2.29	63	10.6	Y
14	68	M	IgG κ	60	39	625	6	2.61	82	11.6	Y
15	73	M	IgG κ	ND	26	ND	ND	1.96	272	9.2	Y
16	47	M	IgG κ	30-40	10	ND	ND	2.18	50	13.3	Y
17	68	F	IgG λ	40-50	23	ND	ND	2.23	40	13.1	Y
18	45	F	IgG λ	70-80	28	<4	130	2.17	58	10.4	Y
19	47	F	IgG κ	30-40	35	ND	ND	2.42	60	11.4	N
20	69	F	IgG κ	10-15	23	ND	ND	2.32	116	9.9	Y

CRAB: Hypercalcaemia defined as corrected serum calcium >0.25 mmol/l above upper limit of normal or >2.75 mmol/l; renal insufficiency if serum creatinine >173 μmol/l; anaemia if haemoglobin 2 g/dl below lower limit of normal or <10 g/dl; bone lesions defined by ≥ 1 lytic lesion seen on SS departmental report.

BMT, bone marrow trephine; ND, no data.