Table 1.
Characteristics of study population
| Total | Current smokers | Former smokers | Never smokers | p-valuea | |
|---|---|---|---|---|---|
| N | 724 | 195 | 319 | 210 | |
| Age (years) | 59.9 (8.2) | 58.1 (6.7) | 61.5 (8.6) | 59.2 (8.4) | 0.15 |
| Sex (male) | 334 (46 %) | 98 (50 %) | 155 (49 %) | 78 (37 %) | 0.008 |
| BMI (kg/m2) | 27.6 (4.6) | 26.8 (4.3) | 28.0 (4.5) | 27.7 (4.9) | 0.05 |
| Proportion CD8+ T-cellsb | 0.09 (0.05) | 0.10 (0.05) | 0.09 (0.06) | 0.10 (0.05) | 0.81 |
| Proportion CD4+ T-cellsb | 0.26 (0.08) | 0.27 (0.07) | 0.26 (0.08) | 0.26 (0.08) | 0.33 |
| Proportion NK cellsb | 0.14 (0.06) | 0.11 (0.06) | 0.14 (0.06) | 0.14 (0.06) | <0.001 |
| Proportion B-cellsb | 0.10 (0.04) | 0.10 (0.04) | 0.10 (0.03) | 0.10 (0.04) | 0.59 |
| Proportion monocytesb | 0.08 (0.03) | 0.08 (0.03) | 0.08 (0.03) | 0.08 (0.03) | 0.55 |
| Proportion granulocytesb | 0.37 (0.11) | 0.38 (0.11) | 0.37 (0.12) | 0.37 (0.11) | 0.12 |
| Nr. erythrocytes (109/L) | 4.90 (0.37) | 4.86 (0.36) | 4.93 (0.37) | 4.88 (0.38) | 0.67 |
| Nr. platelets (109/L) | 283.8 (63.9) | 293.2 (69.3) | 280.2 (61.0) | 280.4 (62.4) | 0.05 |
| Fasting (yes)c | 717 (99 %) | 192 (99 %) | 315 (99 %) | 210 (100 %) | 0.07 |
| Alcohol (g/day) | 18.2 (11.3) | 19.3 (12.8) | 18.9 (11.5) | 16.0 (8.9) | 0.002 |
| RNA quality score | 8.38 (0.51) | 8.36 (0.50) | 8.39 (0.49) | 8.38 (0.54) | 0.66 |
| Type 2 diabetes mellitus | 53 (7.3 %) | 7 (3.6 %) | 34 (10.6 %) | 12 (5.7 %) | 0.31 |
| Total cholesterol (mmol/L) | 5.6 (1.3) | 5.6 (1.1) | 5.6 (1.5) | 5.6 (1.1) | 0.88 |
| Triglycerides (mmol/L) | 1.49 (0.87) | 1.68 (1.14) | 1.43 (0.68) | 1.39 (0.80) | 0.005 |
| Systolic blood pressure (mmHg) | 135.7 (61.7) | 132.3 (61.7) | 137.5 (64.3) | 136.3 (57.6) | 0.50 |
| Diastolic blood pressure (mmHg) | 84.9 (63.3) | 83.5 (61.7) | 85.6 (66.7) | 85.1 (59.7) | 0.79 |
Data are mean (SD) or n (%)
aCurrent versus never
bHouseman-estimated white blood cell proportions
cThe subjects who provided blood in fasting condition