Table 4.
Characteristics of significant CpG sites
| Average beta-values (SD) | ||||||
|---|---|---|---|---|---|---|
| CpG site | Gene | Positiona | Placement | Current smokers | Former smokers | Never smokers |
| cg24908166 | TERT | 5:1,268,800 | Body | 0.893 (0.031) | 0.900 (0.029) | 0.908 (0.024) |
| cg12324353 | TERT | 5:1,269,197 | Body | 0.846 (0.027) | 0.851 (0.027) | 0.855 (0.024) |
| cg03725309 | SARS | 1:109,757,585 | Body | 0.292 (0.057) | 0.297 (0.060) | 0.311 (0.063) |
| cg00980784 | GNGT2 | 17:47,287,577 | TSS1500 | 0.331 (0.048) | 0.340 (0.048) | 0.341 (0.048) |
| cg13916835 | SMG6 | 17:2,025,181 | Body | 0.796 (0.049) | 0.812 (0.047) | 0.822 (0.039) |
| cg09469355 | SKI | 1:2,161,886 | Body | 0.500 (0.041) | 0.516 (0.045) | 0.520 (0.040) |
| cg05603985 | SKI | 1:2,161,049 | First exon | 0.347 (0.037) | 0.362 (0.038) | 0.364 (0.037) |
| cg04324276 | TOM1L2 | 17:17,817,462 | Body | 0.502 (0.047) | 0.502 (0.046) | 0.507 (0.047) |
| cg25468516 | SIPA1 | 11:65,408,028 | 5′UTR | 0.215 (0.048) | 0.218 (0.051) | 0.226 (0.054) |
| cg22907952 | MRAS | 3:138,121,287 | 3′UTR | 0.806 (0.033) | 0.809 (0.034) | 0.812 (0.030) |
| cg15474579 | CDKN1A | 6:36,753,790 | Body | 0.706 (0.058) | 0.718 (0.052) | 0.726 (0.047) |
| cg20496896 | LRRC2 | 3:46,579,532 | Body | 0.728 (0.056) | 0.727 (0.055) | 0.712 (0.056) |
| cg09397246 | FES | 15:91,427,361 | TSS1500 | 0.296 (0.066) | 0.285 (0.065) | 0.286 (0.062) |
| cg26405020 | FES | 15:91,427,363 | TSS1500 | 0.464 (0.057) | 0.459 (0.059) | 0.457 (0.055) |
| cg18236066 | RPH3A | 12:113,293,823 | Body | 0.702 (0.040) | 0.709 (0.038) | 0.713 (0.041) |
TSS1500, 1500 base pairs for transcription start sites
aBased on genome build 37