Table 2. Top 10 upregulated and downregulated protein-coding genes by TNFα in HRMEC.
| Gene Symbol | Log2 Fold Change | Adjusted P Value | Ensembl ID |
|---|---|---|---|
| Upregulated Genes | |||
| LAD1 |
6.421452313 |
1.10E-07 |
ENSG00000159166 |
| CSF2 |
6.39995987 |
<0.000001 |
ENSG00000164400 |
| TNFAIP6 |
6.358926206 |
2.18E-154 |
ENSG00000123610 |
| CX3CL1 |
6.121874962 |
<0.000001 |
ENSG00000006210 |
| CXCL10 |
5.706389982 |
6.14E-222 |
ENSG00000169245 |
| HLA-DOB |
5.667011352 |
5.01E-13 |
ENSG00000241106 |
| ETV3L |
5.616009893 |
1.07E-05 |
ENSG00000253831 |
| CCL5 |
5.487915198 |
5.76E-257 |
ENSG00000161570 |
| TNF |
5.486418289 |
4.71E-52 |
ENSG00000232810 |
| GBP7 |
5.455106479 |
1.78E-05 |
ENSG00000213512 |
| Downregulated Genes | |||
| RBM20 |
−4.29030613 |
0.009588413 |
ENSG00000203867 |
| PAK6 |
−4.29073104 |
0.026177447 |
ENSG00000137843 |
| OR1F1 |
−4.291371288 |
0.00855682 |
ENSG00000168124 |
| MYO18B |
−4.474679753 |
0.004370114 |
ENSG00000133454 |
| CSRNP3 |
−4.474760229 |
0.004370114 |
ENSG00000178662 |
| CR1 |
−4.634084683 |
0.003662894 |
ENSG00000203710 |
| ARL14 |
−4.783629776 |
0.001145234 |
ENSG00000179674 |
| STOX2 |
−4.915666474 |
0.000890805 |
ENSG00000173320 |
| FAM151A |
−4.916414121 |
0.000585614 |
ENSG00000162391 |
| MUC20 | −5.040180048 | 0.000485122 | ENSG00000176945 |
Transcript fold change and adjusted p value of transcripts affected by TNFα-treated HRMEC compared to vehicle-treated were determined by the edgeR algorithm.