Table 3. Top 10 protein-encoding genes that were upregulated or downregulated by GSK0660 in TNFα-treated HRMEC.
| Gene Symbol | Log2 Fold Change | Adj P Value | Ensembl ID |
|---|---|---|---|
| Upregulated Genes | |||
| CBFA2T3 |
4.970269827 |
0.001038075 |
ENSG00000129993 |
| FAM151A |
4.837332922 |
0.002008674 |
ENSG00000162391 |
| MUC20 |
4.702950855 |
0.011947675 |
ENSG00000176945 |
| STOX2 |
4.133641693 |
0.027737782 |
ENSG00000173320 |
| ARL14 |
4.133638802 |
0.027737782 |
ENSG00000179674 |
| BEAN1 |
3.364047225 |
0.004043429 |
ENSG00000166546 |
| WISP2 |
3.130060871 |
0.012964106 |
ENSG00000064205 |
| GPLD1 |
3.129996475 |
0.012964106 |
ENSG00000112293 |
| UBASH3A |
2.850826781 |
0.04000081 |
ENSG00000160185 |
| GOLGA8R |
2.850824538 |
0.04000081 |
ENSG00000186399 |
| Downregulated Genes | |||
| KIT |
−1.992297751 |
3.64E-30 |
ENSG00000157404 |
| PKD2L2 |
−2.016705824 |
0.026490386 |
ENSG00000078795 |
| LCP2 |
−2.553894739 |
0.000489648 |
ENSG00000043462 |
| TMPRSS9 |
−2.784724078 |
0.006155424 |
ENSG00000178297 |
| FOXG1 |
−2.834209583 |
0.039176409 |
ENSG00000176165 |
| CH25H |
−3.087262332 |
0.014984916 |
ENSG00000138135 |
| CCL8 |
−3.445451904 |
0.000244835 |
ENSG00000108700 |
| HIST1H3J |
−4.043009187 |
0.039661319 |
ENSG00000197153 |
| CCDC73 |
−4.252616175 |
0.022003857 |
ENSG00000186714 |
| SERPING1 | −4.25281999 | 0.022002453 | ENSG00000149131 |
Transcript fold change and adjusted p value were determined using the edgeR algorithm.