Table 1.
Size and electrophysiological properties in TG neurons classified based on current signature
| Type/Strains | n | Size (range), μm | Cm, pF | Rm, MΩ | Em, mV | IH, pA/pF | TOC, pA/pF |
|---|---|---|---|---|---|---|---|
| Type 1 | |||||||
| C57BL/6 | 16 | 18.8 ± 0.5 (15–22) | 8.5 ± 0.8 | 740 ± 213 | −49.5 ± 3.4 | — | — |
| BALB/c | 19 | 17.2 ± 0.8 (12–22) | 8.3 ± 1.1 | 946 ± 219 | −56.2 ± 3.0 | — | — |
| Type 2 | |||||||
| C57BL/6 | 28 | 25.2 ± 0.7 (20–32)* | 15.1 ± 0.7* | 1178 ± 97 | −54.6 ± 1.9 | — | 9.9 ± 1.4‡ |
| BALB/c | 24 | 24.5 ± 0.5 (20–29)* | 14.9 ± 1.3* | 937 ± 137 | −52.5 ± 3.7 | — | 14.9 ± 2.3‡ |
| Type 4 | |||||||
| C57BL/6 | 4 | 30.3 ± 2.3 (24–34)* | 24.0 ± 3.2* | 48 ± 7† | −61.8 ± 3.9 | 23.9 ± 5.6‡ | — |
| BALB/c | 6 | 28.7 ± 1.2 (26–34)* | 20.4 ± 1.9* | 87 ± 34† | −56.5 ± 5.8 | 29.2 ± 11.6‡ | — |
| Type 9 | |||||||
| C57BL/6 | 5 | 27.2 ± 1.3 (25–32)* | 19.4 ± 2.0* | 288 ± 115 | −54.8 ± 7.8 | — | — |
| BALB/c | 5 | 29.4 ± 1.8 (23–33)* | 16.1 ± 3.0 | 100 ± 33 | −41.4 ± 3.8 | — | — |
| Type 13 | |||||||
| C57BL/6 | 8 | 26.8 ± 1.1 (22–32)* | 17.4 ± 1.0* | 196 ± 87† | −46.9 ± 3.2 | 4.7 ± 0.8 | 4.6 ± 1.3 |
| BALB/c | 9 | 28.0 ± 0.9 (23–31)* | 17.6 ± 1.1* | 290 ± 124 | −46.0 ± 4.6 | 3.4 ± 0.5 | 7.6 ± 1.4 |
Values represent means ± SE; n is the cell number for each cell type in either the C57BL/6 or BALB/c mouse strain.
TG, trigeminal ganglion; Cm, membrane capacitance; Rm, membrane resistance; Em, resting membrane potential; TOC, transient outward current; IH, hyperpolarization-activated inward current.
There were no significant differences in these electrophysiological parameters of each cell type between strains (Mann-Whitney U-test).
Significantly larger than type 1 (Dunn's multiple post hoc test following Kruskal-Wallis test).
Significantly smaller than type 2 (Dunn's multiple post hoc test following Kruskal-Wallis test).
Significantly larger than type 13 (Mann-Whitney U-test).