Table 2.

Comparison of thermal pain sensation between C57BL/6 and BALB/c

			C57BL/6J (s)		BALB/cJ (s)
Project/Pain Tests	Sex	Regions	n	Means ± SE	n	Means ± SE
Mogil1
Tail-flick test, 47.5°C	Male	Tail	5	5.8 ± 0.6	5	8.7 ± 0.5*
Tail-flick test, 49°C	Male	Tail	10	2.2 ± 0.1	10	4.6 ± 0.2*
Hargreaves' test	Male	Hind paw	6	8.2 ± 0.3	6	16.3 ± 1.7*
Hot-plate test	Male	Hind paw	8	19.3 ± 1.7	8	32.7 ± 3.7*
Jaxwest1
Hot-plate test	Male	Hind paw	8	5.5 ± 0.7	8	11.1 ± 1.3*
Hot-plate test	Female	Hind paw	8	6.4 ± 0.6	8	10.6 ± 1.1*
This study
Hargreaves' test	Female	Hind paw	15	3.4 ± 0.2	15	7.5 ± 0.3*
Hargreaves' test	Female	Whisker pad	15	2.4 ± 0.1	15	8.3 ± 0.5*

Values represent means ± SE; n = number of animals. Thermal pain behavior data from the “Heritability of Nociception Project,” which is publicly available (http://www.jax.org/phenome).

^*P < 0.01, with Mann-Whitney U test.