Table 3.
Summary of mouse TG cell types and previously reported properties in rats
| Capsaicin Sensitivity |
Previously Reported Properties |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Type | Cell Size | Rm | Em | IB4 | C57BL/6 | BALB/c | Rats | CGRP | SP | Innervation |
| 1 | S | High | High | ± | ± | ± | ± | + | − | NR |
| 2 | S/M | High | High | + | ± | −* | +† | − | − | H-skin |
| 4 | M | Low | Low | − | − | − | − | − | − | H-skin |
| 9 | M | Low | High | − | ± | ± | +† | + | ± | H-skin |
| 13 | M | Low | High | + | ± | −* | +† | NR | NR | G-skin |
For cell size, 11- to 22-μm and 23- to 34-μm cell diameter represent small (S) and medium (M), respectively. Findings for capsaicin sensitivity are relative to previous studies for rat TG neurons (Xu et al. 2010; Ono et al. 2010). The remaining properties are from previous studies on rat dorsal root ganglion (DRG) neurons (Petruska et al. 2000a,b, 2002; Rau et al. 2005, 2006, 2007, 2014; Jiang et al. 2006, 2013; Jiang and Cooper 2011).
IB4, isolectin B4; CGRP, calcitonin gene-related polypeptide; SP, substance P.
“+” And “−” indicate the presence and absence, respectively. NR indicates no report. H-skin and G-skin indicate hairy and glabrous skins, respectively. Note that there is a difference in capsaicin sensitivity in type 1 between Wister TG(±) and Sprague-Dawley DRG(+).
Difference for C57BL/6.
Difference for both mouse strains.