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. 2015 Jan 14;113(9):3356–3374. doi: 10.1152/jn.00460.2014

Fig. 2.

Fig. 2.

Spontaneous termination of seizure in the network model. A, top: image plot of the membrane voltage of all pyramidal (PY) neurons (light colors indicate depolarized potentials) from the network of 10 PY and 2 interneuron (IN) cells; bottom (in black): activity of a single representative PY neuron from the network (neuron #5). Transient direct current (DC) stimulation (2 s) was applied to all PY cells (indicated by large, black arrow). The membrane voltage revealed several state transitions between tonic (fast runs; bottom right) and clonic (bursting; bottom left) periods before termination of seizure-like activity. B: time evolution of [K+]o (red curve), [Na+]i (blue curve), and intracellular chloride concentration ([Cl−])i (green curve).