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. 2015 Jan 14;113(9):3356–3374. doi: 10.1152/jn.00460.2014

Fig. 5.

Fig. 5.

Decrease of the Na/K pump performance triggers seizure. A: juxtacellular recording of a single PY neuron from the CA3 region in a hippocampal slice. Application of 500 nM STDN triggers epileptiform activity. B and C: neuron activity at expanded time scales. Bar (B) indicates time period expanded in C. Note single burst event (C). D: distribution of interspike intervals (ISIs) in vitro after STDN application. The peak near 0 indicates ISIs within burst events. E: simulation of in vitro-like conditions. Membrane voltage of a single representative PY neuron from the network (10 PY and 2 IN cells) after Na+/K+ pump performance was reduced to 50%. Arrow indicates time moment when pump was alternated. F: dynamics of [K+]o (red), [Na+]i (blue), and [Cl−]i (green). G and H: simulated activity at expanded time scales. Bar (G) indicates time period expanded in H. I: distribution of ISIs in the model after the Na+/K+ pump was alternated. Note peak distribution similar to in vitro data (compare with D).