Fig. 6.

Local reduction of the Na⁺/K⁺ pump triggers seizure-like activity in the scaled-up network. A: raster plot of activity in the network of 100 PYs and 25 INs. The Na⁺/K⁺ pump was reduced for PY neurons #48–52 at time = 50 s (black arrow), leading to recurrent seizure-like activity that initiated and terminated spontaneously. B and C: time evolution of [K⁺]_o and [Na⁺]_i, respectively. D: membrane voltage of the representative neuron in the middle of the network (cell #50). E: activity of the neuron #30 during the 2nd episode of seizure, marked by a black line in D. F: activity in the neuron #50 for the same period as in E.