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Mechanism of aptamer–siRNA chimera-mediated targeting and silencing. Target specificity by the RNA chimera can be achieved both at level of the aptamer (PMSA-specific) as well as at the level of the siRNA (by silencing cancer cell-specific survival factors). This approach leads to selective killing of cancer cells that express both the cell surface receptor PSMA and prostate cancer-specific survival factors (e.g. Plk1 and Bcl2).
