Figure 3.

Molecules associated with macrophage subsets. M1 macrophages, also called classically activated, respond to stimuli such as LPS, IFN-γ, and are important producers of pro-inflammatory cytokines. M2 macrophages, also called alternatively active respond to stimuli such as IL-4 or IL-13, are producer of anti-inflammatory cytokines. Tumor-associated macrophages (TAM) respond to self-tumor microenvironment and secrete cytokines such as TGF-β or IL-10. CD169⁺ macrophages are involved in immune tolerance and erythropoiesis. TCR⁺ macrophages are a new subpopulation of macrophages that release chemokine CCL2 and play a role in inflammatory and infectious diseases. Names in black = usually described. Names in white = under specific circumstances can be present in different concentrations.