Table 1.
Characteristics of acute lymphoblastic leukemia patients in the test and validation cohorts.
| Characteristic | Subjects, n (%) |
||
|---|---|---|---|
| QcALL |
DFCI (EFS data) | ||
| Neurotoxicity data | EFS data | ||
|
| |||
| Sex | |||
| Male | 177 (55.3) | 186 (54.9) | 125 (45.5) |
| Female | 143 (44.7) | 153 (45.1) | 150 (54.5) |
|
| |||
| Age | |||
| <10 years | 256 (80) | 269 (79.4) | 225 (81.8) |
| Older than 10 years | 64 (20) | 70 (20.6) | 50 (18.2) |
|
| |||
| WBC | |||
| <50 × 109/l | 267 (83.4) | 277 (81.7) | 222 (80.7) |
| >50 × 109/l | 53 (16.6) | 60 (17.7) | 53 (19.3) |
|
| |||
| Lineage | |||
| B-cell | 289 (90.3) | 305 (90) | 251 (91.3) |
| T-cell | 26 (8.1) | 29 (8.6) | 22 (8) |
| Unknown | 5 (1.6) | 5 (1.5) | 2 (0.7) |
|
| |||
| Risk group | |||
| Standard | 156 (48.8) | 161 (47.5) | 168 (61.1) |
| High and very high | 164 (51.3) | 178 (52.5) | 107 (38.9) |
|
| |||
| DNA index | |||
| >1.16 | 56 (17.5) | 58 (17.1) | |
| <1.16 | 237 (74.1) | 247 (72.9) | |
| Unknown | 27 (8.4) | 34 (10) | |
|
| |||
| DFCI protocol | |||
| 87-01 | 25 (7.8) | 31 (9.1) | |
| 91-01 | 60 (18.8) | 63 (18.6) | |
| 95-01 | 118 (36.9) | 124 (36.6) | 94 (34.2) |
| 00-01 | 117 (36.6) | 121 (35.7) | 181 (65.8) |
Number of patients evaluated for neurotoxicity and EFS in the QcALL cohort is 320 and 339, respectively.
Patients in the validation cohort whose DNA index was not available are shown by empty table cells.
DFCI: Dana-Farber Cancer Institute; EFS: Event-free survival; QcALL: Quebec acute lymphoblastic leukemia; WBC: White blood cell.