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. Author manuscript; available in PMC: 2016 May 22.
Published in final edited form as: Circ Res. 2015 May 22;116(11):1800–1809. doi: 10.1161/CIRCRESAHA.116.305421

Figure 1. The Bcl-2 family members and their domains.

Figure 1

Schematic showing the 25 human Bcl-2 family members separated by their anti- vs pro- apoptotic activities and the domains they contain. Each family member is characterized by containing at least one Bcl-2 homology (BH) domain. Over half of the family members contain a transmembrane (TM) domain which allows for the insertion into various organelles. Unique to Bcl-rambo is an additional domain (BHNo). Bcl2L12 contains a unique domain with 1 proline rich (PR) region and 6 PxxP motifs.