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. Author manuscript; available in PMC: 2016 May 22.
Published in final edited form as: Circ Res. 2015 May 22;116(11):1800–1809. doi: 10.1161/CIRCRESAHA.116.305421

Figure 4. PARP-dependent necrotic pathway.

Figure 4

Upon an extensive amount of DNA damage PARP becomes over activated as a repair response, but in the process NAD+ levels can plummet. For a glycolytic-dependent cell this type of NAD+ depletion stress leads to a complete inhibition of ATP production and eventual necrotic cell death.