Skip to main content
. 2015 May 26;6:73. doi: 10.3389/fendo.2015.00073

Figure 3.

Figure 3

Possible functions of IRS-associated proteins (IRSAPs). (A) IRS-associated proteins modulate IGF/insulin signal intensity through various mechanisms. Some IRSAPs regulate post-translational modification of IRSs. Other IRSAPs interact with IRSs through recognition of post-translationally modified IRSs. These modification and/or protein-interaction regulate the availability to IGF-IR or IR. (B) IRS-associated proteins control stability of IRSs proteins. (C) IRS-associated proteins transport IRSs to specific organelles. (D) IRSs interact with RNA directly or through RNA-binding protein. This complex might control RNA metabolism.