Table 4.

IRS-associated proteins that are involved in RNA metabolism.

IRS-associated protein	IRS isoforms	Functions in the RNA metabolism	Reference
eIF4E	IRS-1	Involved in directing ribosomes to the cap structure of mRNAs at the step of protein synthesis	(88)
eIF4G	IRS-1	Scaffold protein involved in the formation of the eIF4F complex on the cap structure of mRNA	(88)
PABPC1	IRS-1	Required for the 3′-poly(A) tail shortening and translation initiation of mRNA	(88)
SAM68	IRS-1	Alternative splicing regulator whose function depends on its protein modification in response to extracellular cues	(200)