Table 4.

Changes in the calf thickness in mice with NTX-induced muscle atrophy.

Groups	Calf thicknesses (mm)			Changes after the test article treatment period (mm) [B − A]
	At NTX	At 14 days after NTX, first administration [A]	Sacrifice [B]
Controls
Sham	2.70 ± 0.07	2.85 ± 0.10	3.25 ± 0.12	0.40 ± 0.12
NTX	2.69 ± 0.09	2.22 ± 0.06c	2.03 ± 0.11a	−0.19 ± 0.11a
Reference
Oxymetholone	2.70 ± 0.08	2.22 ± 0.07c	2.45 ± 0.10ab	0.23 ± 0.11ab
EESF treated
500 mg/kg	2.69 ± 0.05	2.23 ± 0.04c	2.44 ± 0.12ab	0.21 ± 0.10ab
250 mg/kg	2.69 ± 0.07	2.22 ± 0.04c	2.33 ± 0.07ab	0.11 ± 0.06ab
125 mg/kg	2.69 ± 0.06	2.22 ± 0.04c	2.30 ± 0.06ab	0.08 ± 0.06ab

Values are expressed as mean ± S.D. of 10 mice.

^a p < 0.01 as compared with sham control mice by the LSD test.

^b p < 0.01 as compared with NTX control mice by the LSD test.

^c p < 0.01 as compared with sham control mice by the MW test.