Table 9.
Changes in the gastrocnemius muscle histomorphometrical analysis in mice with NTX-induced muscle atrophy.
| Groups | Histomorphometry of the gastrocnemius muscle bundles | ||
|---|---|---|---|
| Mean muscle fiber diameter (μm/fiber) | Number of infiltrated inflammatory cells (cells/mm2) | Regions occupied by collagen fibers (%/mm2) | |
| Controls | |||
| Sham | 53.23 ± 7.21 | 5.90 ± 1.52 | 5.98 ± 3.06 |
| NTX | 14.81 ± 3.14a | 327.10 ± 96.04a | 40.11 ± 6.34a |
| Reference | |||
| Oxymetholone | 29.64 ± 2.30ab | 86.60 ± 41.21ab | 23.04 ± 2.66ab |
| EESF treated | |||
| 500 mg/kg | 29.94 ± 3.02ab | 89.00 ± 22.67ab | 23.50 ± 4.11ab |
| 250 mg/kg | 29.90 ± 3.74ab | 124.00 ± 15.61ab | 27.50 ± 5.30ab |
| 125 mg/kg | 24.34 ± 4.23ab | 148.10 ± 31.97ab | 31.34 ± 6.01ab |
Values are expressed as mean ± S.D. of 10 mice.
a p < 0.01 as compared with sham control mice by the MW test.
b p < 0.01 as compared with NTX control mice by the MW test.