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. Author manuscript; available in PMC: 2016 May 20.
Published in final edited form as: Neuron. 2015 Apr 30;86(4):1029–1040. doi: 10.1016/j.neuron.2015.03.063

Figure 2. VU0409551 potentiates NMDAR-independent synaptic plasticity in the hippocampus.

Figure 2

(A-B) VU0409551 potentiates DHPG-induced long term depression (LTD). (A) Bath application of 75 μM DHPG for 10 min (open circle, solid line) resulted in LTD of the fEPSP slope. In contrast, bath application of 25 μM DHPG for 10 min (gray circles, solid line) resulted in a slight decrease in fEPSP slope 55 min after compound washout. Application of 10 μM VU0409551 for 10 min (dashed line), first alone and then in combination with 25 μM DHPG (solid line) for 10 min (black circles), resulted in a significant LTD in fEPSP slope (p = 0.0005, n = 6 - 7). Inset shows representative fEPSP traces for each condition for baseline (black trace) and 55 min after compound washout (gray trace). (B) Quantification of the change in fEPSP slope measured 55 min after compound washout. Data represent mean ± S.E.M. ** p < 0.01, *** p < 0.001 when compared with 25 μM DHPG.

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