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. Author manuscript; available in PMC: 2016 May 20.
Published in final edited form as: Neuron. 2015 Apr 30;86(4):1029–1040. doi: 10.1016/j.neuron.2015.03.063

Figure 4. In contrast to other mGlu5 PAMs, VU0409551 does not potentiate NMDAR-mediated hippocampal synaptic plasticity.

Figure 4

(A) VU0409551 does not potentiate NMDAR-mediated, theta burst stimulation-induced long term potentiation (LTP). Saturation TBS resulted in a significant increase in fEPSP slope 35 min after stimulation. Threshold TBS resulted in a small increase in fEPSP slope measured 35 min after stimulation. Bath application of 10 μM VU0409551 for 20 min, followed by threshold TBS, resulted in no change in fEPSP slope from threshold TBS alone. In contrast, bath application of 1 μM VU0092273 for 20 min, followed by threshold TBS, resulted in a significant enhancement of fEPSP slope measured 35 min after stimulation. Inset shows representative fEPSP traces for each condition for baseline (black trace) and 35 min after TBS (gray trace). (B) Quantification of the change in fEPSP slope measured 35 min after TBS stimulation. In contrast to VU0092273, bath application of VU0409551 for 20 min followed by threshold TBS did not result in significant LTP 35 min after stimulation (p = 0.0002, n = 6 - 11). Data represent mean ± S.E.M. ** p < 0.01, when compared with threshold TBS.

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