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Effects of CRP (10μg/ml), IL-6 (1ng/ml) and Dox (10 μg/ml) alone and in combination on yields of 4-androstenedione (pmol) from 14C-testosterone as substrate. Yields of another metabolite 4-androstenedione (4-A) are shown in response to optimal concentrations of CRP, IL-6 and doxycycline (Dox) alone and in combinations of CRP+IL-6, CRP+IL-6 and CRP+IL-6+Dox. C: Control; n=8, p<0.001.
