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. Author manuscript; available in PMC: 2015 May 26.
Published in final edited form as: Circulation. 2015 Mar 4;131(14):1278–1290. doi: 10.1161/CIRCULATIONAHA.114.013303

Figure 3.

Figure 3

lncRNA sequence conservation and expression profiles through vertebrate evolution and development. A through C, Dynamic expression pattern in developing mouse and zebrafish embryos for Terminator (A), Alien (B), and Punisher (C) as determined by quantitative reverse transcription–polymerase chain reaction (n=5 per group). D, Vertebrate genomic alignments and PhyloP conservation scores for each uncharacterized lncRNA across 44 species. See Table V in the online-only Data Supplement for the full list of animals used for PhyloP conservation analysis.1–7 Data are represented as mean±SD. E indicates embryonic day; hpf, hours postfertilization; and MEF, mouse embryonic fibroblast.