Fig. 2.

Representative traces of 1 experiment of glucose deprivation (0 mM) in a young slice (1–2 months of age), showing fEPSP amplitude (A), NADH fluorescence (B), and tissue Po₂ (C). Severe glucose deprivation results in the eventual complete suppression of fEPSP (A) and a severe decline of NADH fluorescence. Tissue Po₂ decreased immediately on onset of the low-glucose condition because of a moderate increase in oxygen utilization. But, with the severe substrate deprivation both oxygen utilization and metabolic demand declined as the fEPSP failed. Abbreviation: fEPSP, field excitatory postsynaptic potential.