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. Author manuscript; available in PMC: 2016 May 22.
Published in final edited form as: Circ Res. 2015 May 22;116(11):1835–1849. doi: 10.1161/CIRCRESAHA.116.306374

Figure 4. Molecular events leading to selective mitophagy of dysfunctional mitochondria.

Figure 4

Left; mitochondrial depolarization or other impairment interrupts normal proteolytic processing of PINK1 kinase. PINK1 accumulates on the OMM and phosphorylates Mfn2, promoting its recruitment of Parkin, and ubiquitin (Ub), enabling its utilization by Parkin. Poly-ubiquitinated OMM proteins bind p62 linked to autophagosomal LC3, thus targeting the mitochondrion for mitophagy.