Figure 1. Schematic of Light-Controlled Motor Recruitment and Organelle Transport in Cells.
(A) CRY2 is anchored to organelles via specific organelle targeting transmembrane domain. CIB1 is linked to truncated kinesin KIF5A. Upon blue light exposure, CIB1-CRY2 binding recruits kinesin motors to organelles, which drives organelles towards the plus end of microtubule.
(B) CIB1 domain is linked to BICDN, a dynein/dynactin adaptor protein. When illuminated with blue light, CIB1 binds with CRY2 and thus recruits dynein to organelles. Consequently, organelles are propelled towards the minus end of microtubule.