Table 4. False-positive rate of digital mammography for detecting invasive cancer by breast density and age and breast density and BCSC 5-year risk.
| BI-RADS Breast Density* | ||||
|---|---|---|---|---|
| Almost entirely fat | Scattered fibroglandular densities | Heterogeneously dense | Extremely dense | |
| Age (years) | False-positive rate per 1000 mammograms (95% CI) | |||
| 40 – 49 | 65 (61, 69) | 123 (120, 125) | 147 (145, 149) | 113 (110, 117) |
| 50 – 59 | 53 (51, 56) | 94 (93, 96) | 117 (115, 119) | 95 (91, 99) |
| 60 – 69 | 51 (48, 53) | 82 (81, 84) | 100 (98, 102) | 74 (69, 80) |
| 70 – 74 | 50 (46, 55) | 77 (74, 80) | 95 (91, 99) | 62 (51, 74) |
| BCSC 5-year risk† | ||||
| 0 - <1.00% | 53 (52, 55) | 106 (104, 108) | 131 (129, 134) | 96 (91, 101) |
| 1.00-1.66% | 54 (51, 57) | 91 (89, 92) | 125 (123, 128) | 99 (95, 103) |
| 1.67-2.49% | 55 (50, 60) | 86 (84, 89) | 115 (113, 118) | 107 (102, 113) |
| ≥2.50% | 65 (52, 81) | 90 (87, 93) | 119 (117, 122) | 101 (96, 106) |
*
Breast Imaging Reporting and Data System (BI-RADS); CI, confidence interval
†
Breast Cancer Surveillance Consortium (BCSC) 5-year risk calculated using age, race, first degree family history of breast cancer, history of breast biopsy, BI-RADS density. Risk categories are defined as low (0-<1.00%), average (1.00-1.66%), intermediate (1.67%-2.49%), high (2.5%-3.99%) and very high (>3.99%).
Bold numbers outside minimally accepted cut-points: false-positive rate >120/1000 mammograms.