N |
|
voxels |
Number of voxels in a tissue |
Vi
|
|
cc |
Volume of a voxel |
Vt
|
|
cc |
Volume of a tissue |
Y |
0.626, 0.0717 |
Sv−1
|
Characterizes the dose-dependency of promotion |
X |
0.151, 2.40 |
years/Sv |
Characterizes the dose-dependency of initiation |
δ
|
1.68, 0.0193 |
10−3 years−1
|
Describes homeostatic regulation of the number of pre-malignant stem cells per niche |
b |
0.282, 0.217 |
years−1
|
Pre-malignant niche replication rate |
Ty
|
10 |
years |
Time since exposure |
Tx
|
60 |
years |
Age at exposure |
D(i) |
|
Sv |
Total dose for all fractions to a given voxel |
d(i,k) |
|
Sv |
Fraction dose to a given voxel |
K |
38 |
fractions |
Number of fractions |
I(i,k) |
|
Sv |
Helps to describe the number of cells initiated |
F(i,k) |
|
- |
Clone survival probability |
v |
602.6, 251.2 |
cells |
Number of stem cells present before irradiation |
n- or
+(i,k) |
|
cells |
Normal stem cell number before (-) and after (+) fraction |
S(i,k) |
|
- |
Surviving fraction of cells |
Z |
602.6, 251.2 |
cells/niche |
Carrying capacity for pre-malignant stem cells per niche |
α
|
0.25 |
Sv−1
|
Stem cell radiation inactivation constant |
β
|
0.025 |
Sv−2
|
Stem cell radiation inactivation constant |
λ
|
0.05, 0.10 |
time−1
|
Maximum net proliferation rate (repopulation) |
n-(K+1) |
v |
cells |
Number of stem cells at large time after exposure |
F(K) |
1 |
- |
Clone survival probability after last fraction |