Table 1.
Canonical pathways overrepresented by upregulated genes in CD14+ monocytes in BD patients
| Ingenuity Canonical Pathways |
Molecules | p-values |
|---|---|---|
| Interferon Signaling | IFIT3, IFIT1, IFITM3, OAS1, JAK1, MX1, BAX, IFITM1 | 5.62E-05 |
| Mouse Embryonic Stem Cell Pluripotency | IL6ST, TCF4, JAK1, SOS1, SOS2, PIK3R5, BMPR2, PIK3CB, SMAD5, FZD1, STAT3, TCF3, FZD2 | 1.00E-04 |
| TGF-β Signaling | TGFBR2, IRF7, JUN, CDC42, SOS2, SOS1, SMAD7, BMPR2, SMURF2, VDR, SMAD5, ACVR1B | 2.29E-04 |
| Systemic Lupus Erythematosus Signaling | LSM14B, CD79B, NFATC3, SOS2, PIK3R5, FCGR1A, PTPRC, SNRNP48, CD3G, RNPC3, JUN, CBL, NFAT5, LSM12, SOS1, PRPF6, PIK3CB, FCGR1B | 4.17E-04 |
| EGF Signaling | CSNK2A2, JAK1, JUN, SOS2, MAP3K1, SOS1, PIK3R5, PIK3CB, STAT3 | 4.37E-04 |
| B Cell Receptor Signaling | CD79B, POU2F2, NFATC3, SOS2, MAP3K1, PIK3R5, TCF3, PTPRC, EBF1, CAMK2D, NFAT5, JUN, DAPP1, CDC42, SOS1, PIK3CB, MAP3K3 | 5.50E-04 |
| Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency | IL6ST, RIF1, JAK1, SOS2, SOS1, PIK3R5, BMPR2, PIK3CB, STAT3, FZD1, SMAD5, FZD2 | 1.51E-03 |
| T Cell Receptor Signaling | PTPRC, CD3G, NFAT5, JUN, CBL, NFATC3, SOS2, MAP3K1, SOS1, PIK3R5, PIK3CB | 1.70E-03 |
| Glucocorticoid Receptor Signaling | JAK1, PRKAB2, POU2F2, NFATC3, HSPA1A/HSPA1B, MAP3K1, SOS2, PIK3R5, HSPA6, STAT3, FCGR1A, TGFBR2, CD3G, HSP90B1, JUN, NFAT5, TAF5, SMARCA2, SOS1, PIK3CB, TAF15 | 2.24E-03 |
| Activation of IRF by Cytosolic Pattern Recognition Receptors | IFIH1, IRF7, JUN, DDX58, ZBP1, SIKE1, IFIT2, ISG15 | 3.09E-03 |
| SAPK/JNK Signaling | JUN, NFATC3, CDC42, SOS2, MAP3K1, SOS1, PIK3R5, PIK3CB, MAP4K5, MAP3K3 | 3.31E-03 |
| Wnt/β-catenin Signaling | TCF4, CSNK1G1, FRAT1, GNAQ, BMPR2, FZD1, TCF3, ACVR1B, TGFBR2, CSNK2A2, JUN, NLK, RARA, TLE4, FZD2 | 3.47E-03 |
| PDGF Signaling | CSNK2A2, JAK1, JUN, SOS2, MAP3K1, SOS1, PIK3R5, PIK3CB, STAT3 | 4.37E-03 |
| PKCθ Signaling in T Lymphocytes | CD3G, NFAT5, JUN, CAMK2D, NFATC3, SOS2, MAP3K1, SOS1, PIK3R5, PIK3CB, MAP3K3 | 4.68E-03 |
| IL-2 Signaling | CSNK2A2, JAK1, JUN, SOS2, SOS1, PIK3R5, PIK3CB | 5.89E-03 |
| Molecular Mechanisms of Cancer | TCF4, JAK1, SOS2, PIK3R5, BMPR2, SMAD5, FZD1, CDKN2B, TGFBR2, CAMK2D, NLK, JUN, SOS1, HIPK2, FZD2, SMAD7, GNAQ, BAX, AURKA, TCF3, NBN, CBL, CDC42, RBPJ, PIK3CB | 7.24E-03 |
| ErbB2-ErbB3 Signaling | NRG1, JUN, SOS2, SOS1, PIK3R5, PIK3CB, STAT3 | 7.94E-03 |
| PPARα/RXRα Activation | PRKAB2, CPT1B, CD36, SOS2, GNAQ, BMPR2, NR2C2, ACVR1B, TGFBR2, HSP90B1, JUN, GPD2, SOS1, INSR | 8.51E-03 |
| PTEN Signaling | TGFBR2, CSNK2A2, CBL, CDC42, SOS2, SOS1, PIK3R5, BMPR2, PIK3CB, INSR, IGF2R | 9.12E-03 |
| JAK/Stat Signaling | JAK1, JUN, SOS2, SOS1, PIK3R5, GNAQ, PIK3CB, STAT3 | 9.55E-03 |
| HGF Signaling | JUN, CDC42, SOS2, MAP3K1, SOS1, PIK3R5, PIK3CB, STAT3, MAP3K3, ELF1 | 1.07E-02 |
| Acute Myeloid Leukemia Signaling | TCF4, RARA, SOS2, SOS1, PIK3R5, PIK3CB, STAT3, TCF3 | 1.12E-02 |
| Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes | TGFBR2, CD3G, NFAT5, JUN, NFATC3, SOS2, MAP3K1, SOS1 | 1.29E-02 |
| CD28 Signaling in T Helper Cells | PTPRC, CD3G, NFAT5, JUN, ARPC5L, NFATC3, CDC42, MAP3K1, PIK3R5, PIK3CB | 1.29E-02 |
| CNTF Signaling | IL6ST, JAK1, SOS1, PIK3R5, PIK3CB, STAT3 | 1.35E-02 |
| Epithelial Adherens Junction Signaling | TGFBR2, TCF4, ACTA2, ARPC5L, CDC42, FER, WASL, BMPR2, TCF3, IQGAP1, CLIP1, ACVR1B | 1.38E-02 |
| Role of NFAT in Regulation of the Immune Response | CD3G, JUN, NFAT5, CD79B, CSNK1G1, NFATC3, SOS1, SOS2, GNAQ, PIK3R5, PIK3CB, FCGR1A, FCGR1B | 1.41E-02 |
| Lysine Degradation II | AASDH, AASDHPPT | 1.55E-02 |
| Lysine Degradation V | AASDH, AASDHPPT | 1.55E-02 |
| April Mediated Signaling | NFAT5, JUN, NFATC3, TNFSF13, MAP3K1 | 1.91E-02 |
| Renal Cell Carcinoma Signaling | JUN, CDC42, SOS2, SOS1, PIK3R5, PIK3CB, ARNT | 2.34E-02 |
| IL-4 Signaling | NFAT5, JAK1, NFATC3, SOS2, SOS1, PIK3R5, PIK3CB | 2.51E-02 |