Table 2. Concordance between tumor HPV DNA and anti-HPV antibodies.

Antibodies	HPV-16 DNA negative	HPV-16 DNA positive	κ statistic (95% CI)
	n = 106 (%)	n = 37 (%)
HPV-16 VLP
Negative	82 (77)	14 (38)	0.36 (0.20-0.53)
Positive	24 (23)	23 (62)
HPV-16 E6
Negative	103 (97)	12 (32)	0.70 (0.56-0.84)
Positive	3 (3)	25 (68)
HPV-16 E7
Negative	103 (97)	13 (35)	0.68 (0.54-0.82)
Positive	3 (3)	24 (65)
HPV-16 E6 and/or E7
Negative	101 (95)	9 (24)	0.74 (0.61-0.87)
Positive	5 (5)	28 (76)

NOTE: HPV DNA results from paraffin-embedded tissues available for 145 patients at the time of analysis; two cases were excluded because their tumors were detected with HPV-33.