Table 3. Association between Subcortical Volumes and Lifetime AUD.

Brain region	Lifetime AUD vs unaffected, unrelated controlsa	Lifetime AUD vs unaffected 1st degree relativea	Lifetime AUD vs Unaffected 2–5th degree relativea	Past AUD vs Current AUDa
Nucleus accumbens	0.202, p=0.653	0.453, p=0.501	1.290, p=0.256	0.154, p=0.695
Amygdala	8.807, p=0.003	1.725, p=0.189	0.831, p=0.362	2.08, p=0.149
Caudate	0.221, p=0.638	0.438, p=0.508	0.165, p=0.685	0.933, p=0.334
Hippocampus	0.089, p=0.765	0.003, p=0.956	3.457, p=0.063	0.736, p=0.391
Inferior lateral ventricle	7.879, p=0.005	6.465, p=0.011	3.981, p=0.046	6.47, p=0.001
Lateral ventricle	0.002, p=0.989	1.274, p=0.259	3.170, p=0.075	0.031, p=0.860
Pallidum	0.014, p=0.907	2.690, p=0.101	4.135, p=0.042	1.284, p=0.257
Putamen	0.581, p=0.446	0.531, p=0.466	2.484, p=0.115	1.965, p=0.161
Thalamus	0.182, p=0.670	2.304, p=0.129	6.038, p=0.014	2.443, p=0.118
Ventral diencephalon	1.133, p=0.287	0.243, p=0.622	3.085, p=0.079	2.189, p=0.139

^aχ², p-value, bolded cells were significant after correction for multiple comparisons.