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. 2014 Sep 17;40(2):502–512. doi: 10.1038/npp.2014.199

Figure 3.

Figure 3

Anxiety-like behavior (EZM). (a) Time spent in open arm, (b) Time spent in head dipping behavior, (c) Time spent in stretch/attend posture. All data represent mean±SEM (n=10/group). Sal-aCSF: saline treatment IP with aCSF administered ICV, Sal-Etan: saline treatment IP with etanercept administered ICV, LPS-aCSF: LPS challenge IP with aCSF administered ICV, LPS-Etan: LPS challenge IP with etanercept administered ICV. Data compared using two-way ANOVA; ((a) Interaction: P=0.42, Saline/LPS challenge: P=0.28, aCSF/etanercept treatment: P=0.04; (b) Time in head dipping behavior: Interaction: P=0.44, Saline/LPS challenge: P<0.001, aCSF/etanercept treatment: P=0.0023; (c) Stretch–attend posture: Interaction: P=0.096, Saline/LPS challenge: P=0.0006, aCSF/etanercept treatment: P=0.0008). **P<0.01 LSP-aCSF compared with Sal-aCSF mice, #P<0.05, ##P<0.01 LPS-Etan compared with LPS-aCSF mice, analyzed by Bonferroni's multiple comparisons.