Skip to main content
. Author manuscript; available in PMC: 2015 May 26.
Published in final edited form as: Ther Targets Neurol Dis. 2015;2(1):e471. doi: 10.14800/ttnd.471

Fig 1. Schematic diagram demonstrating signaling pathways involved in Tat101-mediated induction of PDGF-BB & pericyte migration.

Fig 1

Tat stimulates MAPK (Erk and JNK) pathways, which in turn, leads to nuclear translocation of NF-κB, with subsequent induction of PDGF-BB. Elevated PDGF-BB via autocrine PDGFR-β signaling, ultimately leads to increased pericyte migration and loss in microvessels within the brain.