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ML283 Analogue with Optimal Antiviral Activity in Cells
| ||||
|---|---|---|---|---|
| compd (CID) | DENV ATPase IC50a (μM) | DENV helicase IC50a (μM) | replicon EC50b (μM) | TIc |
| 24 (49849289) | 0.5 ± 0.1 | 1.5 ± 0.2 | 7.1±3 | 17 |
As defined in Table 1.
Half-maximal inhibitory concentration observed in assays monitoring BHK cell DENV replicon content.
Half-maximal inhibitory concentration observed in BHK cell viability assays (CC50)/replicon EC50.
