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. Author manuscript; available in PMC: 2016 Mar 13.
Published in final edited form as: ACS Infect Dis. 2015 Jan 21;1(3):140–148. doi: 10.1021/id5000458

Table 3.

DENV Helicase Inhibitors Active against DENV Replicons but Not the HCV Helicase

graphic file with name nihms689963u4.jpg
Cmpd (CID) R1, R2 ATPase IC50 (μM)a Replicon EC50 (μM)b T.I.b
25 (45382104) graphic file with name nihms689963t1.jpg   78±23 36±6 4.5
26 (45382103) graphic file with name nihms689963t2.jpg 27±8   59±14 3.5
27 (4594423) graphic file with name nihms689963t3.jpg 147±72   60±21 5.4
28 (45382102) graphic file with name nihms689963t4.jpg   93±25 104±48 2.1
29 (4473963) graphic file with name nihms689963t5.jpg 30±8 125±93 2.0
30 (45382099) graphic file with name nihms689963t6.jpg 29±9 147±38 7.2
a

As defined in Table 1.

b

As defined in Table 2.