Table 6. Sensitivity of BD RIDTs for Influenza A in comparison to RT-PCR reported in different studies.
| Reference | Region | season | Test | total number of samples (n) | No. of Influenza A PCR positive samples (n) | Sensitivity for Influenza A (%) | Specificity for Influenza A (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|---|---|---|
| This study | Germany | 2003–2004 | BD Directigen Flu A+B | 267 | 44 | 44 | |||
| 2006–2007 | |||||||||
| 2007–2008 | |||||||||
| 2008–2009 | |||||||||
| 2010–2011 | BD Directigen EZ Flu A+B | 200 | 59 | 59 | |||||
| 2011–2012 | |||||||||
| 2012–2013 | |||||||||
| Al Johani et al., 2011 [5] | Saudi Arabia | June 2009 | BD Directigen EZ Flu A+B | 143 | 34 | 21 | 99 | 87.5 | 80.0 |
| TruFlu | 143 | 5 | 10 | 98 | 60.0 | 77.5 | |||
| Cheng et al., 2011 [6] | China | September 2009 | BD Directigen EZ Flu A+B | 807 | 235 | 71 | 99.8 | 99.4 | 89.6 |
| FluA Dot | 807 | 235 | 91 | 99.7 | 99.1 | 97.0 | |||
| Blázquez et al., 2010 [17] | Spanien | Juni-August 2009 | BD Directigen EZ Flu A+B | 71 | 70 | 100 | 100 | 76.6 | |
| Vasoo et al., 2009 [4] | USA | May- June 2009 | BD Directigen EZ Flu A+B | n.d. | 84 | 47 | 100 | 100 | 89.6 |
| BinaxNOW Influenza A&B | n.d. | 84 | 38 | 100 | 100 | 88.2 | |||
| QuickVue Influenza A+B | n.d. | 84 | 53 | 100 | 100 | 90.8 | |||
| Liao et al., 2009 [2] | Canada | 2006–2007 | BD Directigen Flu A+B | 180 | 51 | 59 | 99.2 | 96.8 | 85.9 |
| 2007–2008 | |||||||||
| Gröndahl et al.,2005 [3] | Germany | 2002–2003 | BD Directigen Flu A+B | 299 | 41 | 29 | 99.2 | 85.7 | 89.9 |
n.d. not determined