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. 2015 May 26;10(5):e0129239. doi: 10.1371/journal.pone.0129239

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© 2015 Flaherty et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 5 — (A) Late-stage iRBC were treated with 1 μM FITC-conjugated STAD-2 for 2 hours and probed for P. falciparum PKA-R (top panel) or H. sapiens PKA-RII (bottom panel). STAD-2 did not show clear colocalization with either of the regulatory subunits. (B) Late-stage iRBC were treated with 1 μM STAD-2, 30 μM H89 (small molecule inhibitor of PKA), or 0.001% DMSO and analyzed by light microscopy at 48 hours post-treatment. H89-treated iRBC demonstrated clear absence of parasite digestive vacuoles while STAD-2 treated iRBC were indistinguishable from DMSO controls.