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. 2015 May 26;10(5):e0127512. doi: 10.1371/journal.pone.0127512

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© 2015 Huan et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 2 — siRNA-RFD, siRNA targeting the replication foci domain (RFD) of Dnmt1, siRNA-BAH, siRNA targeting the bromo adjacent homology domain (BAH) of Dnmt1, and siRNA-DCM, siRNA targeting the cytosine-C5 specific DNA methylase domain (DCM) of Dnmt1. After siRNAs were injected into GV stage oocytes, the interference efficiencies were mensurated in matured MII stage oocytes. siRNA-RFD, siRNA-BAH and siRNA-DCM significantly reduced the expression of Dnmt1, and the interference level of siRNA-DCM was the highest. ^a-eValues with different superscripts differed significantly (P<0.05).